Path ID: DBSALT001045_MESH_D003233_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| DB:DBSALT001045 | Ketorolac tromethamine | Drug |
| UniProt:P35354 | Prostaglandin G/H synthase 2 | Protein |
| UniProt:P23219 | Prostaglandin G/H synthase 1 | Protein |
| MESH:D011453 | Prostaglandins | ChemicalSubstance |
| GO:0006954 | Inflammatory response | BiologicalProcess |
| MESH:D003233 | Allergic conjunctivitis | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Ketorolac Tromethamine | DECREASES ACTIVITY OF | Prostaglandin G/H Synthase 2 |
| Ketorolac Tromethamine | DECREASES ACTIVITY OF | Prostaglandin G/H Synthase 1 |
| Prostaglandin G/H Synthase 2 | INCREASES ABUNDANCE OF | Prostaglandins |
| Prostaglandin G/H Synthase 1 | INCREASES ABUNDANCE OF | Prostaglandins |
| Prostaglandins | PARTICIPATES IN | Inflammatory Response |
| Inflammatory Response | POSITIVELY CORRELATED WITH | Allergic Conjunctivitis |
Comment: In the DrugCentral the drug trometamol (tromethamine) was indicated for allergic conjunctivitis, however no literature evidences found about the mechanism of action of trometamol treating allergic conjunctivitis. For the treatment of allergic conjunctivitis the ketorolac tromethamine is used.
Reference: