Path ID: DB14512_MESH_D003877_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D000068656 | mometasone furoate | Drug |
| UniProt:P04150 | Glucocorticoid receptor | Protein |
| GO:0071385 | cellular response to glucocorticoid stimulus | BiologicalProcess |
| GO:0006954 | inflammatory response | BiologicalProcess |
| HP:0000989 | Pruritus | PhenotypicFeature |
| HP:0000988 | Skin rash | PhenotypicFeature |
| MESH:D003877 | Dermatitis, Contact | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Mometasone Furoate | INCREASES ACTIVITY OF | Glucocorticoid Receptor |
| Glucocorticoid Receptor | POSITIVELY REGULATES | Cellular Response To Glucocorticoid Stimulus |
| Cellular Response To Glucocorticoid Stimulus | NEGATIVELY REGULATES | Inflammatory Response |
| Inflammatory Response | POSITIVELY CORRELATED WITH | Pruritus |
| Inflammatory Response | POSITIVELY CORRELATED WITH | Skin Rash |
| Pruritus | MANIFESTATION OF | Dermatitis, Contact |
| Skin Rash | MANIFESTATION OF | Dermatitis, Contact |
Comment: Mometasone furoate is a corticosteroid and acts as a prodrug of mometasone. Mometasone is not currently used in medical products.
Reference: