Path ID: DB13167_MESH_D001172_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C084615 | Alclofenac | Drug |
| UniProt:P35354 | Prostaglandin G/H synthase 2 | Protein |
| reactome:R-HSA-2162123 | Synthesis of Prostaglandins (PG) and Thromboxanes (TX) | BiologicalProcess |
| MESH:D011453 | Prostaglandins | ChemicalSubstance |
| GO:0006954 | Inflammatory response | BiologicalProcess |
| HP:0002829 | Joint pain | PhenotypicFeature |
| HP:0001386 | Joint swelling | PhenotypicFeature |
| MESH:D001172 | Rheumatoid arthritis | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Alclofenac | DECREASES ACTIVITY OF | Prostaglandin G/H Synthase 2 |
| Prostaglandin G/H Synthase 2 | PARTICIPATES IN | Synthesis Of Prostaglandins (Pg) And Thromboxanes (Tx) |
| Synthesis Of Prostaglandins (Pg) And Thromboxanes (Tx) | INCREASES ABUNDANCE OF | Prostaglandins |
| Prostaglandins | POSITIVELY REGULATES | Inflammatory Response |
| Inflammatory Response | POSITIVELY CORRELATED WITH | Joint Pain |
| Inflammatory Response | POSITIVELY CORRELATED WITH | Joint Swelling |
| Joint Swelling | POSITIVELY CORRELATED WITH | Rheumatoid Arthritis |
| Joint Pain | POSITIVELY CORRELATED WITH | Rheumatoid Arthritis |
Comment: Alclofenac was withdrawn from the market in the United Kingdom in 1979.
Reference: