Path ID: DB13165_MESH_D005901_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C584679 | K-115 | Drug |
| UniProt:Q13464 | Rho-associated protein kinase 1 | Protein |
| UniProt:O75116 | Rho-associated protein kinase 2 | Protein |
| GO:0006939 | smooth muscle contraction | BiologicalProcess |
| UBERON:0005969 | eye trabecular meshwork | GrossAnatomicalStructure |
| UBERON:0003956 | aqueous drainage system | GrossAnatomicalStructure |
| HP:0007906 | Ocular hypertension | PhenotypicFeature |
| MESH:D005901 | Glaucoma | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| K-115 | DECREASES ACTIVITY OF | Rho-Associated Protein Kinase 1 |
| K-115 | DECREASES ACTIVITY OF | Rho-Associated Protein Kinase 2 |
| Rho-Associated Protein Kinase 1 | POSITIVELY REGULATES | Smooth Muscle Contraction |
| Rho-Associated Protein Kinase 2 | POSITIVELY REGULATES | Smooth Muscle Contraction |
| Smooth Muscle Contraction | OCCURS IN | Eye Trabecular Meshwork |
| Eye Trabecular Meshwork | POSITIVELY REGULATES | Aqueous Drainage System |
| Aqueous Drainage System | CORRELATED WITH | Ocular Hypertension |
| Ocular Hypertension | CONTRIBUTES TO | Glaucoma |
Reference: