Path ID: DB13139_MESH_D001986_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D064412 | levosalbutamol | Drug |
| UniProt:P07550 | Beta-2 adrenergic receptor | Protein |
| UniProt:B7Z2C7 | Adenylate cyclase | Protein |
| CHEBI:17489 | 3’,5’-cyclic AMP | ChemicalSubstance |
| UniProt:P17612 | cAMP-dependent protein kinase catalytic subunit alpha | Protein |
| GO:0044557 | smooth muscle relaxation | BiologicalProcess |
| GO:0070509 | transmembrane calcium influx | BiologicalProcess |
| UBERON:0002185 | bronchus | GrossAnatomicalStructure |
| MESH:D001986 | Bronchospasm | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Levosalbutamol | INCREASES ACTIVITY OF | Beta-2 Adrenergic Receptor |
| Beta-2 Adrenergic Receptor | POSITIVELY REGULATES | Adenylate Cyclase |
| Adenylate Cyclase | INCREASES ABUNDANCE OF | 3’,5’-Cyclic Amp |
| 3’,5’-Cyclic Amp | INCREASES ACTIVITY OF | Camp-Dependent Protein Kinase Catalytic Subunit Alpha |
| Camp-Dependent Protein Kinase Catalytic Subunit Alpha | POSITIVELY REGULATES | Smooth Muscle Relaxation |
| Camp-Dependent Protein Kinase Catalytic Subunit Alpha | NEGATIVELY REGULATES | Transmembrane Calcium Influx |
| Smooth Muscle Relaxation | LOCATED IN | Bronchus |
| Transmembrane Calcium Influx | LOCATED IN | Bronchus |
| Bronchus | CORRELATED WITH | Bronchospasm |
Reference: