Path ID: DB13132_MESH_D016778_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C031327 | artemisinin | Drug |
| CHEBI:207229 | dihydroartemisinin | ChemicalSubstance |
| UniProt:Q8I3Z5 | Translationally controlled tumor protein (TCTP) homolog | Protein |
| taxonomy:5833 | Plasmodium falciparum | OrganismTaxon |
| MESH:D016778 | Falciparum malaria | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Artemisinin | HAS METABOLITE | Dihydroartemisinin |
| Dihydroartemisinin | DECREASES ACTIVITY OF | Translationally Controlled Tumor Protein (Tctp) Homolog |
| Translationally Controlled Tumor Protein (Tctp) Homolog | PART OF | Plasmodium Falciparum |
| Plasmodium Falciparum | CAUSES | Falciparum Malaria |
Comment: The exact mechanism of artemisinin action is not completely understood, It was proposed to generate free-radicals due to its unique structure endoperoxide bridge. The MoA proposed here is the one of the drug target identified for artemisinin mode of action with solid experimental evidence.
Reference: