Path ID: DB13092_MESH_D002006_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C100122 | meclocycline | Drug |
| InterPro:IPR000235 | 30S ribosomal protein S5/S7 | GeneFamily |
| GO:0043039 | tRNA aminoacylation | BiologicalProcess |
| GO:0006412 | Translation | BiologicalProcess |
| taxonomy:234 | Brucella | OrganismTaxon |
| MESH:D002006 | Brucellosis | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Meclocycline | DECREASES ACTIVITY OF | 30S Ribosomal Protein S5/S7 |
| 30S Ribosomal Protein S5/S7 | POSITIVELY REGULATES | Trna Aminoacylation |
| Trna Aminoacylation | PARTICIPATES IN | Translation |
| Translation | IN TAXON | Brucella |
| Brucella | CAUSES | Brucellosis |
Comment: Meclocycline is under investigation in clinical trial NCT00385515, As a tetracycline, meclocycline likely works by reversably associating with the 30s S7 subuint of the bacterial ribosome.
Reference: