Path ID: DB13001_MESH_D010146_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C100290 | tinoridine | Drug |
| UniProt:P23219 | Prostaglandin G/H synthase 1 | Protein |
| UniProt:P35354 | Prostaglandin G/H synthase 2 | Protein |
| reactome:R-HSA-2162123 | Synthesis of Prostaglandins (PG) and Thromboxanes (TX) | Pathway |
| MESH:D011453 | Prostaglandins | ChemicalSubstance |
| MESH:D010146 | Pain | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Tinoridine | DECREASES ACTIVITY OF | Prostaglandin G/H Synthase 1 |
| Tinoridine | DECREASES ACTIVITY OF | Prostaglandin G/H Synthase 2 |
| Prostaglandin G/H Synthase 1 | POSITIVELY REGULATES | Synthesis Of Prostaglandins (Pg) And Thromboxanes (Tx) |
| Prostaglandin G/H Synthase 2 | POSITIVELY REGULATES | Synthesis Of Prostaglandins (Pg) And Thromboxanes (Tx) |
| Synthesis Of Prostaglandins (Pg) And Thromboxanes (Tx) | INCREASES ABUNDANCE OF | Prostaglandins |
| Prostaglandins | POSITIVELY CORRELATED WITH | Pain |
Comment: The drug tinoridine is in clinical trial phase 4.
Reference: