Path ID: DB12975_MESH_D016778_2
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C027871 | Pyronaridine | Drug |
| MESH:D006427 | Hemin | ChemicalSubstance |
| CL:0000232 | erythrocyte | Cell |
| GO:0019954 | asexual reproduction | BiologicalProcess |
| taxonomy:5833 | Plasmodium falciparum | OrganismTaxon |
| MESH:D016778 | Malaria, Falciparum | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Pyronaridine | MOLECULARLY INTERACTS WITH | Hemin |
| Hemin | DISRUPTS | Erythrocyte |
| Erythrocyte | LOCATION OF | Asexual Reproduction |
| Asexual Reproduction | IN TAXON | Plasmodium Falciparum |
| Plasmodium Falciparum | CAUSES | Malaria, Falciparum |
Comment: Hemin (MESH:D006427) and heme (MESH:D006418) are related substances resulting from the parasite hemoglobin catabolism. Heme is bound to iron whereas hemin is the hydroxide counterpart of heme. Both are cytotoxic. Hemin is also known as hematin.
Reference: