Path ID: DB12975_MESH_D016778_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C027871 | Pyronaridine | Drug |
| GO:0042540 | hemoglobin catabolic process | BiologicalProcess |
| MESH:D006418 | Heme | ChemicalSubstance |
| taxonomy:5833 | Plasmodium falciparum | OrganismTaxon |
| MESH:D016778 | Malaria, Falciparum | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Pyronaridine | NEGATIVELY REGULATES | Hemoglobin Catabolic Process |
| Hemoglobin Catabolic Process | INCREASES ABUNDANCE OF | Heme |
| Heme | DISRUPTS | Plasmodium Falciparum |
| Plasmodium Falciparum | CAUSES | Malaria, Falciparum |
Comment: Heme (MESH:D006418) and hemin (MESH:D006427) are related substances resulting from the parasite hemoglobin catabolism. Heme is bound to iron whereas hemin is the hydroxide counterpart of heme. Both are cytotoxic. Hemin is also known as hematin.
Reference: