Path ID: DB12864_MESH_D014353_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D008549 | melarsoprol | Drug |
| MESH:C044719 | melarsen oxide | ChemicalSubstance |
| InterPro:IPR001697 | Pyruvate kinase | GeneFamily |
| CHEBI:17842 | trypanothione | ChemicalSubstance |
| GO:0006096 | glycolytic process | BiologicalProcess |
| taxonomy:5691 | Trypanosoma brucei | OrganismTaxon |
| MESH:D014353 | African trypanosomiasis | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Melarsoprol | HAS METABOLITE | Melarsen Oxide |
| Melarsen Oxide | DISRUPTS | Pyruvate Kinase |
| Melarsen Oxide | DISRUPTS | Trypanothione |
| Trypanothione | IN TAXON | Trypanosoma Brucei |
| Pyruvate Kinase | POSITIVELY REGULATES | Glycolytic Process |
| Glycolytic Process | IN TAXON | Trypanosoma Brucei |
| Trypanosoma Brucei | CAUSES | African Trypanosomiasis |
Comment: This drug can affect both host and parasite Pyruvate kinase, therefore it is highly toxic with many side effects.
Reference: