Path ID: DB12712_MESH_D013610_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C042288 | Pilsicainide | Drug |
| UniProt:Q14524 | Sodium channel protein type 5 subunit alpha | Protein |
| GO:0051899 | Membrane depolarization | BiologicalProcess |
| GO:0060048 | Cardiac muscle contraction | BiologicalProcess |
| GO:0060047 | Heart contraction | BiologicalProcess |
| GO:0010460 | Positive regulation of heart rate | BiologicalProcess |
| MESH:D013610 | Tachyarrhythmia | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Pilsicainide | DECREASES ACTIVITY OF | Sodium Channel Protein Type 5 Subunit Alpha |
| Sodium Channel Protein Type 5 Subunit Alpha | POSITIVELY REGULATES | Membrane Depolarization |
| Membrane Depolarization | POSITIVELY REGULATES | Cardiac Muscle Contraction |
| Cardiac Muscle Contraction | POSITIVELY REGULATES | Heart Contraction |
| Heart Contraction | POSITIVELY CORRELATED WITH | Positive Regulation Of Heart Rate |
| Positive Regulation Of Heart Rate | POSITIVELY CORRELATED WITH | Tachyarrhythmia |
Reference: