Path ID: DB12598_MESH_D003550_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C032855 | nafamostat | Drug |
| InterPro:IPR001873 | Epithelial sodium channel | GeneFamily |
| GO:0070254 | mucus secretion | BiologicalProcess |
| HP:0006536 | Airway obstruction | PhenotypicFeature |
| MESH:D003550 | Cystic fibrosis | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Nafamostat | DECREASES ACTIVITY OF | Epithelial Sodium Channel |
| Epithelial Sodium Channel | POSITIVELY REGULATES | Mucus Secretion |
| Mucus Secretion | POSITIVELY CORRELATED WITH | Airway Obstruction |
| Airway Obstruction | MANIFESTATION OF | Cystic Fibrosis |
Comment: Nafamostat mesilate is expected to work by reducing ENaC activity, stimulating the clearance of mucus and relieving the symptoms of the disease.
Reference: