Path ID: DB12459_MESH_D002289_2
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C056507 | gemcitabine | Drug |
| UniProt:P04818 | Thymidylate synthase | Protein |
| UniProt:P30085 | UMP-CMP kinase | Protein |
| UniProt:P23921 | Ribonucleoside-diphosphate reductase large subunit | Protein |
| GO:0006235 | dTTP biosynthetic process | BiologicalProcess |
| GO:0006225 | UDP biosynthetic process | BiologicalProcess |
| GO:0061731 | ribonucleoside-diphosphate reductase activity | MolecularActivity |
| GO:1904860 | DNA synthesis involved in mitotic DNA replication | BiologicalProcess |
| HP:0031377 | Abnormal cell proliferation | PhenotypicFeature |
| MESH:D002289 | Non-small cell lung cancer | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Gemcitabine | NEGATIVELY REGULATES | Thymidylate Synthase |
| Gemcitabine | NEGATIVELY REGULATES | Ump-Cmp Kinase |
| Gemcitabine | NEGATIVELY REGULATES | Ribonucleoside-Diphosphate Reductase Large Subunit |
| Thymidylate Synthase | POSITIVELY REGULATES | Dttp Biosynthetic Process |
| Ump-Cmp Kinase | POSITIVELY REGULATES | Udp Biosynthetic Process |
| Ribonucleoside-Diphosphate Reductase Large Subunit | POSITIVELY REGULATES | Ribonucleoside-Diphosphate Reductase Activity |
| Dttp Biosynthetic Process | POSITIVELY CORRELATED WITH | Dna Synthesis Involved In Mitotic Dna Replication |
| Udp Biosynthetic Process | POSITIVELY CORRELATED WITH | Dna Synthesis Involved In Mitotic Dna Replication |
| Ribonucleoside-Diphosphate Reductase Activity | POSITIVELY CORRELATED WITH | Dna Synthesis Involved In Mitotic Dna Replication |
| Dna Synthesis Involved In Mitotic Dna Replication | CORRELATED WITH | Abnormal Cell Proliferation |
| Abnormal Cell Proliferation | POSITIVELY CORRELATED WITH | Non-Small Cell Lung Cancer |
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