Path ID: DB12399_MESH_D010003_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C000599293 | polmacoxib | Drug |
| UniProt:P35354 | Prostaglandin G/H synthase 2 | Protein |
| InterPro:IPR001148 | Alpha carbonic anhydrase domain | GeneFamily |
| GO:0045453 | bone resorption | BiologicalProcess |
| reactome:R-HSA-2162123 | Synthesis of Prostaglandins (PG) and Thromboxanes (TX) | BiologicalProcess |
| MESH:D011453 | Prostaglandins | ChemicalSubstance |
| HP:0002829 | Arthralgia | PhenotypicFeature |
| HP:0001386 | Joint swelling | PhenotypicFeature |
| MESH:D010003 | Osteoarthritis | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Polmacoxib | DECREASES ACTIVITY OF | Prostaglandin G/H Synthase 2 |
| Polmacoxib | DECREASES ACTIVITY OF | Alpha Carbonic Anhydrase Domain |
| Alpha Carbonic Anhydrase Domain | POSITIVELY REGULATES | Bone Resorption |
| Bone Resorption | POSITIVELY CORRELATED WITH | Osteoarthritis |
| Prostaglandin G/H Synthase 2 | PARTICIPATES IN | Synthesis Of Prostaglandins (Pg) And Thromboxanes (Tx) |
| Synthesis Of Prostaglandins (Pg) And Thromboxanes (Tx) | INCREASES ABUNDANCE OF | Prostaglandins |
| Prostaglandins | POSITIVELY CORRELATED WITH | Arthralgia |
| Prostaglandins | POSITIVELY CORRELATED WITH | Joint Swelling |
| Joint Swelling | MANIFESTATION OF | Osteoarthritis |
| Arthralgia | MANIFESTATION OF | Osteoarthritis |
Reference: