Path ID: DB12161_MESH_D000071057_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| DB:DB04844 | Tetrabenazine | Drug |
| MESH:C000609690 | Deutetrabenazine | Drug |
| UniProt:Q05940 | Synaptic vesicular amine transporter | Protein |
| GO:0015842 | Aminergic neurotransmitter loading into synaptic vesicle | BiologicalProcess |
| GO:0042420 | Dopamine catabolic process | BiologicalProcess |
| GO:0061527 | Dopamine secretion, neurotransmission | BiologicalProcess |
| MESH:D000071057 | Tardive dyskinesia | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Deutetrabenazine | HAS METABOLITE | Tetrabenazine |
| Tetrabenazine | DECREASES ACTIVITY OF | Synaptic Vesicular Amine Transporter |
| Synaptic Vesicular Amine Transporter | POSITIVELY REGULATES | Aminergic Neurotransmitter Loading Into Synaptic Vesicle |
| Aminergic Neurotransmitter Loading Into Synaptic Vesicle | PREVENTS | Dopamine Catabolic Process |
| Dopamine Catabolic Process | NEGATIVELY REGULATES | Dopamine Secretion, Neurotransmission |
| Dopamine Secretion, Neurotransmission | CORRELATED WITH | Tardive Dyskinesia |
Comment: The presence of deuterium in deutetrabenazine increases the half-lives of the active metabolite and prolongs their pharmacological activity by attenuating CYP2D6 metabolism of the compound.
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