Path ID: DB12159_MESH_D003876_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C582203 | dupilumab | Drug |
| UniProt:P24394 | Interleukin-4 receptor subunit alpha | Protein |
| reactome:R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | Pathway |
| GO:0042092 | type 2 immune response | BiologicalProcess |
| MESH:D003876 | Atopic dermatitis | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Dupilumab | DECREASES ACTIVITY OF | Interleukin-4 Receptor Subunit Alpha |
| Interleukin-4 Receptor Subunit Alpha | PARTICIPATES IN | Interleukin-4 And Interleukin-13 Signaling |
| Interleukin-4 And Interleukin-13 Signaling | POSITIVELY REGULATES | Type 2 Immune Response |
| Type 2 Immune Response | CONTRIBUTES TO | Atopic Dermatitis |
Reference: