Path ID: DB12131_MESH_D003704_2
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C013983 | vinpocetine | Drug |
| Pfam:PF06512 | Sodium ion transport-associated | GeneFamily |
| GO:0098703 | calcium ion import across plasma membrane | BiologicalProcess |
| GO:0055074 | calcium ion homeostasis | BiologicalProcess |
| GO:0051402 | neuron apoptotic process | BiologicalProcess |
| MESH:D005609 | Free Radicals | ChemicalSubstance |
| GO:0036475 | neuron death in response to oxidative stress | BiologicalProcess |
| HP:0001268 | Mental deterioration | PhenotypicFeature |
| HP:0001250 | Seizure | PhenotypicFeature |
| MESH:D003704 | Dementia | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Vinpocetine | NEGATIVELY REGULATES | Calcium Ion Import Across Plasma Membrane |
| Calcium Ion Import Across Plasma Membrane | POSITIVELY CORRELATED WITH | Neuron Apoptotic Process |
| Neuron Apoptotic Process | POSITIVELY CORRELATED WITH | Dementia |
| Calcium Ion Import Across Plasma Membrane | DISRUPTS | Calcium Ion Homeostasis |
| Calcium Ion Homeostasis | NEGATIVELY CORRELATED WITH | Dementia |
| Vinpocetine | NEGATIVELY REGULATES | Sodium Ion Transport-Associated |
| Sodium Ion Transport-Associated | POSITIVELY CORRELATED WITH | Seizure |
| Vinpocetine | DECREASES ABUNDANCE OF | Free Radicals |
| Free Radicals | POSITIVELY CORRELATED WITH | Neuron Death In Response To Oxidative Stress |
| Neuron Death In Response To Oxidative Stress | POSITIVELY CORRELATED WITH | Mental Deterioration |
| Mental Deterioration | MANIFESTATION OF | Dementia |
| Seizure | MANIFESTATION OF | Dementia |
Comment: Vinpocetine is not approved for any therapeutic use in the United States.
Reference: