Path ID: DB11915_MESH_D000071057_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C000603978 | valbenazine | Drug |
| UniProt:Q05940 | Synaptic vesicular amine transporter | Protein |
| GO:0015842 | aminergic neurotransmitter loading into synaptic vesicle | BiologicalProcess |
| reactome:R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | Pathway |
| MESH:D000071057 | Tardive dyskinesia | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Valbenazine | DECREASES ACTIVITY OF | Synaptic Vesicular Amine Transporter |
| Synaptic Vesicular Amine Transporter | POSITIVELY REGULATES | Aminergic Neurotransmitter Loading Into Synaptic Vesicle |
| Aminergic Neurotransmitter Loading Into Synaptic Vesicle | POSITIVELY CORRELATED WITH | Dopamine Neurotransmitter Release Cycle |
| Dopamine Neurotransmitter Release Cycle | POSITIVELY CORRELATED WITH | Tardive Dyskinesia |
Comment: The reviewed (SwissProt) entry is Q05940 (supersedes entry available on DrugBank i.e.Q99870. The Ensembl gene ID is ENSG00000165646)
Reference: