Path ID: DB11820_MESH_D014355_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D009547 | nifurtimox | Drug |
| CHEBI:26523 | reactive oxygen species | ChemicalSubstance |
| CHEBI:16991 | deoxyribonucleic acid | ChemicalSubstance |
| taxonomy:5693 | Trypanosoma cruzi | OrganismTaxon |
| MESH:D014355 | Infection by Trypanosoma cruzi | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Nifurtimox | PRODUCES | Reactive Oxygen Species |
| Reactive Oxygen Species | DISRUPTS | Deoxyribonucleic Acid |
| Deoxyribonucleic Acid | IN TAXON | Trypanosoma Cruzi |
| Trypanosoma Cruzi | CAUSES | Infection By Trypanosoma Cruzi |
Comment: The disease is known as Chagas Disease in MESH (MESH:D014355). The drug is metabolized by nitoreductases (https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/213464s000lbl.pdf) rather than nitoreductases being the target of this drug (https://go.drugbank.com/drugs/DB11820#BE0010011).
Reference: