Path ID: DB11817_MESH_D001172_1

Concepts
Identifier | Name | Type |
---|---|---|
MESH:C000596027 | baricitinib | Drug |
UniProt:P23458 | Tyrosine-protein kinase JAK1 | Protein |
UniProt:O60674 | Tyrosine-protein kinase JAK2 | Protein |
UniProt:P52333 | Tyrosine-protein kinase JAK3 | Protein |
UniProt:P29597 | Non-receptor tyrosine-protein kinase TYK2 | Protein |
GO:0019221 | cytokine-mediated signaling pathway | BiologicalProcess |
GO:0006954 | inflammatory response | BiologicalProcess |
MESH:D001172 | Arthritis, Rheumatoid | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
Subject | Predicate | Object |
---|---|---|
Baricitinib | DECREASES ACTIVITY OF | Tyrosine-Protein Kinase Jak1 |
Baricitinib | DECREASES ACTIVITY OF | Tyrosine-Protein Kinase Jak2 |
Baricitinib | DECREASES ACTIVITY OF | Tyrosine-Protein Kinase Jak3 |
Baricitinib | DECREASES ACTIVITY OF | Non-Receptor Tyrosine-Protein Kinase Tyk2 |
Tyrosine-Protein Kinase Jak1 | POSITIVELY REGULATES | Cytokine-Mediated Signaling Pathway |
Tyrosine-Protein Kinase Jak2 | POSITIVELY REGULATES | Cytokine-Mediated Signaling Pathway |
Tyrosine-Protein Kinase Jak3 | POSITIVELY REGULATES | Cytokine-Mediated Signaling Pathway |
Non-Receptor Tyrosine-Protein Kinase Tyk2 | POSITIVELY REGULATES | Cytokine-Mediated Signaling Pathway |
Cytokine-Mediated Signaling Pathway | POSITIVELY CORRELATED WITH | Inflammatory Response |
Inflammatory Response | CONTRIBUTES TO | Arthritis, Rheumatoid |
Reference:
- https://go.drugbank.com/drugs/DB11817#mechanism-of-action
- https://www.uniprot.org/uniprot/P23458#function
- https://www.uniprot.org/uniprot/O60674#function
- https://www.uniprot.org/uniprot/P52333#function
- https://www.uniprot.org/uniprot/P29597#function
- https://en.wikipedia.org/wiki/Rheumatoid_arthritis