Path ID: DB11817_MESH_D001172_1

db11817-mesh-d001172-1

Concepts

Identifier Name Type
MESH:C000596027 baricitinib Drug
UniProt:P23458 Tyrosine-protein kinase JAK1 Protein
UniProt:O60674 Tyrosine-protein kinase JAK2 Protein
UniProt:P52333 Tyrosine-protein kinase JAK3 Protein
UniProt:P29597 Non-receptor tyrosine-protein kinase TYK2 Protein
GO:0019221 cytokine-mediated signaling pathway BiologicalProcess
GO:0006954 inflammatory response BiologicalProcess
MESH:D001172 Arthritis, Rheumatoid Disease

Relationships

NOTE: predicates are annotated in Biolink Model (v1.3.0)

Subject Predicate Object
Baricitinib DECREASES ACTIVITY OF Tyrosine-Protein Kinase Jak1
Baricitinib DECREASES ACTIVITY OF Tyrosine-Protein Kinase Jak2
Baricitinib DECREASES ACTIVITY OF Tyrosine-Protein Kinase Jak3
Baricitinib DECREASES ACTIVITY OF Non-Receptor Tyrosine-Protein Kinase Tyk2
Tyrosine-Protein Kinase Jak1 POSITIVELY REGULATES Cytokine-Mediated Signaling Pathway
Tyrosine-Protein Kinase Jak2 POSITIVELY REGULATES Cytokine-Mediated Signaling Pathway
Tyrosine-Protein Kinase Jak3 POSITIVELY REGULATES Cytokine-Mediated Signaling Pathway
Non-Receptor Tyrosine-Protein Kinase Tyk2 POSITIVELY REGULATES Cytokine-Mediated Signaling Pathway
Cytokine-Mediated Signaling Pathway POSITIVELY CORRELATED WITH Inflammatory Response
Inflammatory Response CONTRIBUTES TO Arthritis, Rheumatoid

Reference: