Path ID: DB11783_MESH_D006973_2
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C055603 | temocapril hydrochloride | Drug |
| MESH:C069156 | temocaprilat | Drug |
| UniProt:P12821 | Angiotensin-converting enzyme | Protein |
| CHEBI:26333 | prostaglandin | ChemicalSubstance |
| GO:0002003 | angiotensin maturation | BiologicalProcess |
| GO:0042310 | vasoconstriction | BiologicalProcess |
| HP:0032263 | Increased blood pressure | PhenotypicFeature |
| MESH:D006973 | Hypertensive disorder | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Temocapril Hydrochloride | PRODUCES | Temocaprilat |
| Temocaprilat | DECREASES ACTIVITY OF | Angiotensin-Converting Enzyme |
| Temocaprilat | INCREASES ABUNDANCE OF | Prostaglandin |
| Prostaglandin | NEGATIVELY CORRELATED WITH | Vasoconstriction |
| Angiotensin-Converting Enzyme | POSITIVELY REGULATES | Angiotensin Maturation |
| Angiotensin Maturation | POSITIVELY REGULATES | Vasoconstriction |
| Vasoconstriction | POSITIVELY CORRELATED WITH | Increased Blood Pressure |
| Increased Blood Pressure | MANIFESTATION OF | Hypertensive Disorder |
Reference: