Path ID: DB11767_MESH_D001172_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C000592401 | Sarilumab | ChemicalSubstance |
| UniProt:P08887 | Interleukin-6 receptor subunit alpha | Protein |
| GO:0070102 | Interleukin-6-mediated signaling pathway | BiologicalProcess |
| GO:0006954 | Inflammatory response | BiologicalProcess |
| HP:0005187 | Progressive joint destruction | PhenotypicFeature |
| MESH:D001172 | Rheumatoid arthritis | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Sarilumab | DECREASES ACTIVITY OF | Interleukin-6 Receptor Subunit Alpha |
| Interleukin-6 Receptor Subunit Alpha | POSITIVELY REGULATES | Interleukin-6-Mediated Signaling Pathway |
| Interleukin-6-Mediated Signaling Pathway | POSITIVELY REGULATES | Inflammatory Response |
| Inflammatory Response | POSITIVELY REGULATES | Progressive Joint Destruction |
| Progressive Joint Destruction | MANIFESTATION OF | Rheumatoid Arthritis |
Reference: