Path ID: DB11757_MESH_D010300_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C111599 | Istradefylline | Drug |
| UniProt:P29274 | Adenosine receptor A2a | Protein |
| MESH:D000241 | Adenosine | ChemicalSubstance |
| UniProt:P14416 | D(2) dopamine receptor | Protein |
| MESH:D004298 | Dopamine | ChemicalSubstance |
| GO:0001963 | Synaptic transmission, dopaminergic | BiologicalProcess |
| MESH:D010300 | Parkinson’s disease | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Istradefylline | DECREASES ACTIVITY OF | Adenosine Receptor A2A |
| Adenosine Receptor A2A | MOLECULARLY INTERACTS WITH | Adenosine |
| Adenosine | DECREASES ACTIVITY OF | D(2) Dopamine Receptor |
| D(2) Dopamine Receptor | MOLECULARLY INTERACTS WITH | Dopamine |
| Dopamine | POSITIVELY CORRELATED WITH | Synaptic Transmission, Dopaminergic |
| Synaptic Transmission, Dopaminergic | NEGATIVELY CORRELATED WITH | Parkinson’S Disease |
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