Path ID: DB11613_MESH_D019698_1

db11613-mesh-d019698-1

Concepts

Identifier Name Type
MESH:C000604171 velpatasvir Drug
UniProt:Q5L478 Nonstructural protein 5A Protein
GO:0003968 RNA-directed 5’-3’ RNA polymerase activity MolecularActivity
GO:0039694 viral RNA genome replication BiologicalProcess
MESH:C000618292 PI4KIIIalpha protein, human Protein
MESH:C037178 phosphatidylinositol 4-phosphate ChemicalSubstance
MESH:D002784 Cholesterol ChemicalSubstance
MESH:D000086969 Viral Replication Compartments CellularComponent
GO:0004197 cysteine-type endopeptidase activity MolecularActivity
GO:0004252 serine-type endopeptidase activity MolecularActivity
MESH:D014779 Virus Replication BiologicalProcess
MESH:D019065 Virus Assembly BiologicalProcess
taxonomy:11103 Hepacivirus C OrganismTaxon
MESH:D019698 Chronic hepatitis C Disease

Relationships

NOTE: predicates are annotated in Biolink Model (v1.3.0)

Subject Predicate Object
Velpatasvir NEGATIVELY REGULATES Nonstructural Protein 5A
Nonstructural Protein 5A MOLECULARLY INTERACTS WITH Pi4Kiiialpha Protein, Human
Pi4Kiiialpha Protein, Human INCREASES ABUNDANCE OF Phosphatidylinositol 4-Phosphate
Phosphatidylinositol 4-Phosphate POSITIVELY CORRELATED WITH Cholesterol
Cholesterol LOCATED IN Viral Replication Compartments
Viral Replication Compartments LOCATION OF Viral Rna Genome Replication
Nonstructural Protein 5A POSITIVELY REGULATES Rna-Directed 5’-3’ Rna Polymerase Activity
Rna-Directed 5’-3’ Rna Polymerase Activity POSITIVELY REGULATES Viral Rna Genome Replication
Nonstructural Protein 5A POSITIVELY REGULATES Cysteine-Type Endopeptidase Activity
Nonstructural Protein 5A POSITIVELY REGULATES Serine-Type Endopeptidase Activity
Cysteine-Type Endopeptidase Activity POSITIVELY CORRELATED WITH Virus Replication
Serine-Type Endopeptidase Activity POSITIVELY CORRELATED WITH Virus Replication
Virus Replication POSITIVELY CORRELATED WITH Virus Assembly
Viral Rna Genome Replication IN TAXON Hepacivirus C
Virus Assembly IN TAXON Hepacivirus C
Hepacivirus C CAUSES Chronic Hepatitis C

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