Path ID: DB11365_MESH_D003248_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D012676 | Sennosides | Drug |
| DB:DB13175 | Rheinanthrone | Drug |
| UniProt:P35354 | Prostaglandin G/H synthase 2 | Protein |
| UniProt:Q92482 | Aquaporin-3 | Protein |
| GO:0006833 | Water transport | BiologicalProcess |
| GO:0030432 | Peristalsis | BiologicalProcess |
| UBERON:0001155 | Colon | GrossAnatomicalStructure |
| MESH:D003248 | Constipation | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Sennosides | HAS METABOLITE | Rheinanthrone |
| Rheinanthrone | INCREASES ACTIVITY OF | Prostaglandin G/H Synthase 2 |
| Prostaglandin G/H Synthase 2 | DECREASES ACTIVITY OF | Aquaporin-3 |
| Aquaporin-3 | POSITIVELY REGULATES | Water Transport |
| Water Transport | LOCATED IN | Colon |
| Colon | LOCATION OF | Constipation |
| Rheinanthrone | POSITIVELY REGULATES | Peristalsis |
| Peristalsis | NEGATIVELY CORRELATED WITH | Constipation |
Reference: