Path ID: DB11363_MESH_D002289_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C582670 | Alectinib | Drug |
| UniProt:Q9UM73 | ALK tyrosine kinase receptor | Protein |
| reactome:R-HSA-9701898 | STAT3 nuclear events downstream of ALK signalingS | Pathway |
| reactome:R-HSA-109704 | PI3K Cascade | Pathway |
| GO:1904019 | Epithelial cell apoptotic process | BiologicalProcess |
| GO:0050673 | Epithelial cell proliferation | BiologicalProcess |
| UBERON:0002048 | Lung | GrossAnatomicalStructure |
| MESH:D002289 | Non-small cell lung cancer | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Alectinib | DECREASES ACTIVITY OF | Alk Tyrosine Kinase Receptor |
| Alk Tyrosine Kinase Receptor | POSITIVELY REGULATES | Stat3 Nuclear Events Downstream Of Alk Signalings |
| Alk Tyrosine Kinase Receptor | POSITIVELY REGULATES | Pi3K Cascade |
| Stat3 Nuclear Events Downstream Of Alk Signalings | NEGATIVELY REGULATES | Epithelial Cell Apoptotic Process |
| Pi3K Cascade | POSITIVELY REGULATES | Epithelial Cell Proliferation |
| Epithelial Cell Apoptotic Process | OCCURS IN | Lung |
| Epithelial Cell Proliferation | OCCURS IN | Lung |
| Lung | LOCATION OF | Non-Small Cell Lung Cancer |
Comment: Alectinib is specifically used in the treatment of non-small cell lung cancer (NSCLC) expressing the ALK-EML4 (echinoderm microtubule-associated protein-like 4) fusion protein that causes proliferation of NSCLC cells.
Reference: