Path ID: DB11093_MESH_D015663_2
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D019355 | calcium citrate | Drug |
| MESH:D002118 | Calcium | ChemicalSubstance |
| UniProt:P41180 | Extracellular calcium-sensing receptor | Protein |
| GO:0070509 | calcium ion import | BiologicalProcess |
| GO:0035898 | parathyroid hormone secretion | BiologicalProcess |
| GO:0045453 | bone resorption | BiologicalProcess |
| GO:0001503 | ossification | BiologicalProcess |
| HP:0004349 | Reduced bone mineral density | PhenotypicFeature |
| MESH:D015663 | Postmenopausal osteoporosis | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Calcium Citrate | INCREASES ABUNDANCE OF | Calcium |
| Calcium | POSITIVELY REGULATES | Extracellular Calcium-Sensing Receptor |
| Extracellular Calcium-Sensing Receptor | NEGATIVELY REGULATES | Parathyroid Hormone Secretion |
| Parathyroid Hormone Secretion | POSITIVELY CORRELATED WITH | Bone Resorption |
| Bone Resorption | POSITIVELY CORRELATED WITH | Reduced Bone Mineral Density |
| Reduced Bone Mineral Density | POSITIVELY CORRELATED WITH | Postmenopausal Osteoporosis |
| Extracellular Calcium-Sensing Receptor | POSITIVELY REGULATES | Calcium Ion Import |
| Calcium Ion Import | POSITIVELY CORRELATED WITH | Ossification |
| Ossification | NEGATIVELY CORRELATED WITH | Postmenopausal Osteoporosis |
Reference: