Path ID: DB11093_MESH_D015663_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C081587 | strontium ranelate | Drug |
| UniProt:P41180 | Extracellular calcium-sensing receptor | Protein |
| MESH:D053244 | Osteoprotegerin | Protein |
| MESH:D010006 | Osteoblasts | Cell |
| MESH:D010010 | Osteoclasts | Cell |
| GO:0006915 | apoptotic process | BiologicalProcess |
| GO:0070509 | calcium ion import | BiologicalProcess |
| GO:0001503 | ossification | BiologicalProcess |
| GO:0045453 | bone resorption | BiologicalProcess |
| MESH:D015663 | Postmenopausal osteoporosis | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Strontium Ranelate | POSITIVELY REGULATES | Osteoblasts |
| Osteoblasts | INCREASES ABUNDANCE OF | Osteoprotegerin |
| Osteoblasts | INCREASES EXPRESSION OF | Osteoprotegerin |
| Osteoprotegerin | NEGATIVELY CORRELATED WITH | Bone Resorption |
| Bone Resorption | POSITIVELY CORRELATED WITH | Postmenopausal Osteoporosis |
| Strontium Ranelate | POSITIVELY REGULATES | Extracellular Calcium-Sensing Receptor |
| Extracellular Calcium-Sensing Receptor | POSITIVELY CORRELATED WITH | Apoptotic Process |
| Apoptotic Process | DECREASES ABUNDANCE OF | Osteoclasts |
| Osteoclasts | POSITIVELY CORRELATED WITH | Bone Resorption |
| Extracellular Calcium-Sensing Receptor | POSITIVELY REGULATES | Calcium Ion Import |
| Calcium Ion Import | POSITIVELY CORRELATED WITH | Ossification |
| Ossification | NEGATIVELY CORRELATED WITH | Postmenopausal Osteoporosis |
Reference: