Path ID: DB09389_MESH_D008595_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D009644 | Norgestrel | Drug |
| UniProt:P06401 | Progesterone receptor | Protein |
| GO:0050673 | Epithelial cell proliferation | BiologicalProcess |
| MESH:D008595 | Menorrhagia | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Norgestrel | INCREASES ACTIVITY OF | Progesterone Receptor |
| Progesterone Receptor | NEGATIVELY REGULATES | Epithelial Cell Proliferation |
| Epithelial Cell Proliferation | POSITIVELY CORRELATED WITH | Menorrhagia |
Comment: Norgestrel is composed of a racemic mixture of two stereoisomers, dextronorgestrel and levonorgestrel. However, only the levorotary enantiomer (levonorgestrel) is biologically active. There is an evidence indicating that levonorgestrel activates progesteron receptor https://pubmed.ncbi.nlm.nih.gov/16112947/
Reference: