Path ID: DB09345_MESH_D010032_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C005548 | pramocaine | Drug |
| InterPro:IPR001696 | Voltage gated sodium channel, alpha subunit | GeneFamily |
| GO:0006814 | sodium ion transport | BiologicalProcess |
| GO:0086010 | membrane depolarization during action potential | BiologicalProcess |
| GO:0007600 | sensory perception | BiologicalProcess |
| HP:0000989 | Pruritus | PhenotypicFeature |
| HP:0012531 | Pain | PhenotypicFeature |
| MESH:D010032 | Otitis externa | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Pramocaine | NEGATIVELY REGULATES | Voltage Gated Sodium Channel, Alpha Subunit |
| Voltage Gated Sodium Channel, Alpha Subunit | POSITIVELY REGULATES | Sodium Ion Transport |
| Sodium Ion Transport | POSITIVELY CORRELATED WITH | Membrane Depolarization During Action Potential |
| Membrane Depolarization During Action Potential | REGULATES | Sensory Perception |
| Sensory Perception | CORRELATED WITH | Pain |
| Sensory Perception | CORRELATED WITH | Pruritus |
| Pruritus | MANIFESTATION OF | Otitis Externa |
| Pain | MANIFESTATION OF | Otitis Externa |
Reference: