Path ID: DB09343_MESH_D003110_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C000613754 | tipiracil | Drug |
| UniProt:P19971 | Thymidine phosphorylase | Protein |
| GO:0001525 | angiogenesis | BiologicalProcess |
| MESH:D003110 | Malignant tumor of colon | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Tipiracil | DECREASES ACTIVITY OF | Thymidine Phosphorylase |
| Thymidine Phosphorylase | POSITIVELY REGULATES | Angiogenesis |
| Angiogenesis | POSITIVELY CORRELATED WITH | Malignant Tumor Of Colon |
Comment: Tipiracil may also play its anti-neoplastic role indirectly when admnistered in combination with Trifluridine (DB:DB00432). In this case, tipiracil will prevent trifluridine breakdown, thus increasing its bioavailability and boosting its systemiic presence (https://en.wikipedia.org/wiki/Trifluridine/tipiracil).
Reference: