Path ID: DB09335_MESH_D061387_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C106856 | alatrofloxacin | Drug |
| DB:DB00685 | Trovafloxacin | ChemicalSubstance |
| InterPro:IPR035516 | DNA gyrase/topoisomerase IV, subunit A, C-terminal | GeneFamily |
| GO:0006265 | DNA topological change | BiologicalProcess |
| taxonomy:83558 | Chlamydia pneumoniae | OrganismTaxon |
| MESH:D061387 | Chlamydial pneumonia | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Alatrofloxacin | HAS METABOLITE | Trovafloxacin |
| Trovafloxacin | NEGATIVELY REGULATES | Dna Gyrase/Topoisomerase Iv, Subunit A, C-Terminal |
| Dna Gyrase/Topoisomerase Iv, Subunit A, C-Terminal | POSITIVELY REGULATES | Dna Topological Change |
| Dna Topological Change | IN TAXON | Chlamydia Pneumoniae |
| Chlamydia Pneumoniae | CAUSES | Chlamydial Pneumonia |
Comment: Alatrofloxacin is a prodrug of trovafloxacin (https://meshb.nlm.nih.gov/record/ui?ui=C106856). Both are withdrawn from the US market (https://en.wikipedia.org/wiki/Alatrofloxacin).
Reference: