Path ID: DB09304_MESH_D003866_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C050605 | setiptiline | Drug |
| UniProt:P08913 | Alpha-2A adrenergic receptor | Protein |
| UniProt:P18089 | Alpha-2B adrenergic receptor | Protein |
| UniProt:P18825 | Alpha-2C adrenergic receptor | Protein |
| GO:0061533 | norepinephrine secretion, neurotransmission | BiologicalProcess |
| GO:0061529 | epinephrine secretion, neurotransmission | BiologicalProcess |
| MESH:D003866 | Depressive disorder | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Setiptiline | DECREASES ACTIVITY OF | Alpha-2A Adrenergic Receptor |
| Setiptiline | DECREASES ACTIVITY OF | Alpha-2B Adrenergic Receptor |
| Setiptiline | DECREASES ACTIVITY OF | Alpha-2C Adrenergic Receptor |
| Alpha-2A Adrenergic Receptor | CORRELATED WITH | Norepinephrine Secretion, Neurotransmission |
| Alpha-2B Adrenergic Receptor | CORRELATED WITH | Norepinephrine Secretion, Neurotransmission |
| Alpha-2C Adrenergic Receptor | CORRELATED WITH | Norepinephrine Secretion, Neurotransmission |
| Alpha-2A Adrenergic Receptor | CORRELATED WITH | Epinephrine Secretion, Neurotransmission |
| Alpha-2B Adrenergic Receptor | CORRELATED WITH | Epinephrine Secretion, Neurotransmission |
| Alpha-2C Adrenergic Receptor | CORRELATED WITH | Epinephrine Secretion, Neurotransmission |
| Norepinephrine Secretion, Neurotransmission | CORRELATED WITH | Depressive Disorder |
| Epinephrine Secretion, Neurotransmission | CORRELATED WITH | Depressive Disorder |
Reference: