Path ID: DB09302_MESH_D050197_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C571059 | alirocumab | Drug |
| UniProt:Q8NBP7 | Proprotein convertase subtilisin/kexin type 9 | Protein |
| GO:0090118 | receptor-mediated endocytosis involved in cholesterol transport | BiologicalProcess |
| HP:0003141 | Increased LDL cholesterol concentration | PhenotypicFeature |
| HP:0031678 | Atherosclerotic lesion | PhenotypicFeature |
| MESH:D050197 | Atherosclerosis | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Alirocumab | DECREASES ACTIVITY OF | Proprotein Convertase Subtilisin/Kexin Type 9 |
| Proprotein Convertase Subtilisin/Kexin Type 9 | NEGATIVELY REGULATES | Receptor-Mediated Endocytosis Involved In Cholesterol Transport |
| Receptor-Mediated Endocytosis Involved In Cholesterol Transport | NEGATIVELY CORRELATED WITH | Increased Ldl Cholesterol Concentration |
| Increased Ldl Cholesterol Concentration | POSITIVELY CORRELATED WITH | Atherosclerotic Lesion |
| Atherosclerotic Lesion | MANIFESTATION OF | Atherosclerosis |
Reference: