Path ID: DB09299_MESH_D015658_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C442442 | Tenofovir alafenamide | Drug |
| MESH:D000068698 | Tenofovir | ChemicalSubstance |
| UniProt:Q72547 | Reverse transcriptase/RNaseH (Human immunodeficiency virus 1) | Protein |
| GO:0003964 | RNA-directed DNA polymerase activity | BiologicalProcess |
| taxonomy:12721 | Human immunodeficiency virus | OrganismTaxon |
| GO:0019079 | Viral genome replication | BiologicalProcess |
| MESH:D015658 | Human immunodeficiency virus infection | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Tenofovir Alafenamide | HAS METABOLITE | Tenofovir |
| Tenofovir | DECREASES ACTIVITY OF | Reverse Transcriptase/Rnaseh (Human Immunodeficiency Virus 1) |
| Reverse Transcriptase/Rnaseh (Human Immunodeficiency Virus 1) | POSITIVELY REGULATES | Rna-Directed Dna Polymerase Activity |
| Rna-Directed Dna Polymerase Activity | PRECEDES | Viral Genome Replication |
| Viral Genome Replication | IN TAXON | Human Immunodeficiency Virus |
| Human Immunodeficiency Virus | CAUSES | Human Immunodeficiency Virus Infection |
Comment: Tenofovir alafenamide is a prodrug of tenofovir. It is usually combined with other aniviral drugs, such as emtricitabine and bictegravir,for the treatment of HIV-1 infection.
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