Path ID: DB09296_MESH_D019698_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C586094 | ABT-267 | Drug |
| UniProt:Q5L478 | Nonstructural protein 5A | Protein |
| GO:0003968 | RNA-directed 5’-3’ RNA polymerase activity | MolecularActivity |
| GO:0039694 | viral RNA genome replication | BiologicalProcess |
| MESH:C000618292 | PI4KIIIalpha protein, human | Protein |
| MESH:C037178 | phosphatidylinositol 4-phosphate | ChemicalSubstance |
| MESH:D002784 | Cholesterol | ChemicalSubstance |
| MESH:D000086969 | Viral Replication Compartments | CellularComponent |
| GO:0004197 | cysteine-type endopeptidase activity | MolecularActivity |
| GO:0004252 | serine-type endopeptidase activity | MolecularActivity |
| MESH:D014779 | Virus Replication | BiologicalProcess |
| MESH:D019065 | Virus Assembly | BiologicalProcess |
| taxonomy:11103 | Hepacivirus C | OrganismTaxon |
| MESH:D019698 | Chronic hepatitis C | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Abt-267 | NEGATIVELY REGULATES | Nonstructural Protein 5A |
| Nonstructural Protein 5A | MOLECULARLY INTERACTS WITH | Pi4Kiiialpha Protein, Human |
| Pi4Kiiialpha Protein, Human | INCREASES ABUNDANCE OF | Phosphatidylinositol 4-Phosphate |
| Phosphatidylinositol 4-Phosphate | POSITIVELY CORRELATED WITH | Cholesterol |
| Cholesterol | LOCATED IN | Viral Replication Compartments |
| Viral Replication Compartments | LOCATION OF | Viral Rna Genome Replication |
| Nonstructural Protein 5A | POSITIVELY REGULATES | Rna-Directed 5’-3’ Rna Polymerase Activity |
| Rna-Directed 5’-3’ Rna Polymerase Activity | POSITIVELY REGULATES | Viral Rna Genome Replication |
| Nonstructural Protein 5A | POSITIVELY REGULATES | Cysteine-Type Endopeptidase Activity |
| Nonstructural Protein 5A | POSITIVELY REGULATES | Serine-Type Endopeptidase Activity |
| Cysteine-Type Endopeptidase Activity | POSITIVELY CORRELATED WITH | Virus Replication |
| Serine-Type Endopeptidase Activity | POSITIVELY CORRELATED WITH | Virus Replication |
| Virus Replication | POSITIVELY CORRELATED WITH | Virus Assembly |
| Viral Rna Genome Replication | IN TAXON | Hepacivirus C |
| Virus Assembly | IN TAXON | Hepacivirus C |
| Hepacivirus C | CAUSES | Chronic Hepatitis C |
Comment: ABT-267 is also known as ombitasvir (see Other names at https://en.wikipedia.org/wiki/Ombitasvir)..)
Reference:
- https://go.drugbank.com/drugs/DB09296#mechanism-of-action
- https://en.wikipedia.org/wiki/Discovery_and_development_of_NS5A_inhibitors#Mechanism_of_action
- https://en.wikipedia.org/wiki/Discovery_and_development_of_NS5A_inhibitors#Function
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4246218/
- https://www.ncbi.nlm.nih.gov/books/NBK1623/