Path ID: DB09282_MESH_D000787_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D008981 | molsidomine | Drug |
| MESH:C002385 | linsidomine | ChemicalSubstance |
| MESH:D009569 | Nitric Oxide | ChemicalSubstance |
| GO:0004383 | guanylate cyclase activity | MolecularActivity |
| MESH:D006152 | Cyclic GMP | ChemicalSubstance |
| GO:0042311 | vasodilation | BiologicalProcess |
| MESH:D017202 | Myocardial Ischemia | Disease |
| MESH:D000787 | Angina Pectoris | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Molsidomine | HAS METABOLITE | Linsidomine |
| Linsidomine | PRODUCES | Nitric Oxide |
| Nitric Oxide | POSITIVELY REGULATES | Guanylate Cyclase Activity |
| Guanylate Cyclase Activity | INCREASES ABUNDANCE OF | Cyclic Gmp |
| Cyclic Gmp | POSITIVELY CORRELATED WITH | Vasodilation |
| Vasodilation | NEGATIVELY CORRELATED WITH | Myocardial Ischemia |
| Myocardial Ischemia | CONTRIBUTES TO | Angina Pectoris |
Comment: Molsidomine is a drug that is metabolized in the liver to the active metabolite linsidomine which releases nitric oxide, a vasodilating compound.
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