Path ID: DB09265_MESH_D003924_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C479460 | lixisenatide | Drug |
| UniProt:P43220 | Glucagon-like peptide 1 receptor | Protein |
| UniProt:P43220 | Glucagon-like peptide 1 receptor | Protein |
| reactome:R-HSA-381676 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | Pathway |
| reactome:R-HSA-418555 | G alpha (s) signalling events | Pathway |
| GO:0014808 | release of sequestered calcium ion into cytosol by sarcoplasmic reticulum | BiologicalProcess |
| GO:0030073 | insulin secretion | BiologicalProcess |
| MESH:D003924 | Diabetes mellitus type 2 | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Lixisenatide | INCREASES ACTIVITY OF | Glucagon-Like Peptide 1 Receptor |
| Glucagon-Like Peptide 1 Receptor | PARTICIPATES IN | Glucagon-Like Peptide-1 (Glp1) Regulates Insulin Secretion |
| Glucagon-Like Peptide 1 Receptor | PARTICIPATES IN | G Alpha (S) Signalling Events |
| G Alpha (S) Signalling Events | POSITIVELY CORRELATED WITH | Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum |
| Glucagon-Like Peptide-1 (Glp1) Regulates Insulin Secretion | POSITIVELY CORRELATED WITH | Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum |
| Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum | POSITIVELY CORRELATED WITH | Insulin Secretion |
| Insulin Secretion | NEGATIVELY CORRELATED WITH | Diabetes Mellitus Type 2 |
Reference: