Path ID: DB09257_MESH_D013274_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C104201 | Gimeracil | Drug |
| UniProt:Q12882 | Dihydropyrimidine dehydrogenase | Protein |
| MESH:D005472 | Fluorouracil | Drug |
| MESH:D013274 | Malignant tumor of stomach | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Gimeracil | DECREASES ACTIVITY OF | Dihydropyrimidine Dehydrogenase |
| Dihydropyrimidine Dehydrogenase | DECREASES ABUNDANCE OF | Fluorouracil |
| Fluorouracil | TREATS | Malignant Tumor Of Stomach |
Comment: Gimeracil is available in combination with oteracil and tegafur within the commercially available product “Teysuno”. Gimeracil’s main role within Teysuno is to prevent the breakdown of Fluorouracil (5-FU), which helps to maintin high enough concentrations for sustained effect against cancer cells.
Reference: