Path ID: DB09256_MESH_D013274_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D005641 | Tegafur | Drug |
| MESH:D005472 | Fluorouracil | ChemicalSubstance |
| MESH:D005468 | Fluorodeoxyuridylate | ChemicalSubstance |
| MESH:C025635 | 5-fluorouridine 5’-triphosphate | ChemicalSubstance |
| UniProt:P04818 | Thymidylate synthase | Protein |
| GO:0071897 | DNA biosynthetic process | BiologicalProcess |
| GO:0032774 | RNA biosynthetic process | BiologicalProcess |
| CL:0001063 | neoplastic cell | Cell |
| MESH:D013274 | Stomach Neoplasms | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Tegafur | HAS METABOLITE | Fluorouracil |
| Fluorouracil | HAS ACTIVE INGREDIENT | Fluorodeoxyuridylate |
| Fluorouracil | HAS ACTIVE INGREDIENT | 5-Fluorouridine 5’-Triphosphate |
| Fluorodeoxyuridylate | DECREASES ACTIVITY OF | Thymidylate Synthase |
| Thymidylate Synthase | POSITIVELY REGULATES | Dna Biosynthetic Process |
| Dna Biosynthetic Process | OCCURS IN | Neoplastic Cell |
| 5-Fluorouridine 5’-Triphosphate | DISRUPTS | Rna Biosynthetic Process |
| Rna Biosynthetic Process | OCCURS IN | Neoplastic Cell |
| Neoplastic Cell | CONTRIBUTES TO | Stomach Neoplasms |
Comment: Tegafur has the active antineoplastic metabolite, 5-fluorouracil (5-FU). The 5-FU is then converted into 5-fluoro-deoxyuridine-monophosphate and 5-fluorouridine-triphosphate in the cell.
Reference: