Path ID: DB09242_MESH_D000075222_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C043482 | Moxonidine | Drug |
| UniProt:P08913 | Alpha-2A adrenergic receptor | Protein |
| GO:0004938 | Alpha2-adrenergic receptor activity | BiologicalProcess |
| GO:0061533 | Norepinephrine secretion, neurotransmission | BiologicalProcess |
| HP:0000822 | Blood pressure | PhenotypicFeature |
| UniProt:Q9Y2I1 | Nischarin | Protein |
| UBERON:0000013 | Sympathetic nervous system | GrossAnatomicalStructure |
| GO:0045777 | Positive regulation of blood pressure | BiologicalProcess |
| MESH:D000075222 | Essential hypertension | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Moxonidine | INCREASES ACTIVITY OF | Alpha-2A Adrenergic Receptor |
| Alpha-2A Adrenergic Receptor | POSITIVELY CORRELATED WITH | Alpha2-Adrenergic Receptor Activity |
| Alpha2-Adrenergic Receptor Activity | NEGATIVELY REGULATES | Norepinephrine Secretion, Neurotransmission |
| Norepinephrine Secretion, Neurotransmission | POSITIVELY REGULATES | Blood Pressure |
| Blood Pressure | POSITIVELY CORRELATED WITH | Essential Hypertension |
| Moxonidine | INCREASES ACTIVITY OF | Nischarin |
| Nischarin | DECREASES ACTIVITY OF | Sympathetic Nervous System |
| Sympathetic Nervous System | POSITIVELY CORRELATED WITH | Positive Regulation Of Blood Pressure |
| Positive Regulation Of Blood Pressure | POSITIVELY CORRELATED WITH | Essential Hypertension |
Comment: Compared to the older central-acting antihypertensives, moxonidine binds with much greater affinity to the imidazoline I1-receptor than to the α2-receptor.
Reference: