Path ID: DB09221_MESH_D010437_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C061957 | polaprezinc | Drug |
| CHEBI:26523 | reactive oxygen species | ChemicalSubstance |
| taxonomy:210 | Helicobacter pylori | OrganismTaxon |
| GO:0042060 | Wound Healing | BiologicalProcess |
| GO:0006954 | inflammatory response | BiologicalProcess |
| GO:0070254 | mucus secretion | BiologicalProcess |
| MESH:D010437 | Peptic ulcer | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Polaprezinc | DECREASES ABUNDANCE OF | Reactive Oxygen Species |
| Polaprezinc | POSITIVELY CORRELATED WITH | Mucus Secretion |
| Polaprezinc | NEGATIVELY CORRELATED WITH | Inflammatory Response |
| Inflammatory Response | POSITIVELY CORRELATED WITH | Peptic Ulcer |
| Mucus Secretion | NEGATIVELY CORRELATED WITH | Peptic Ulcer |
| Polaprezinc | POSITIVELY CORRELATED WITH | Wound Healing |
| Polaprezinc | NEGATIVELY CORRELATED WITH | Helicobacter Pylori |
| Helicobacter Pylori | CAUSES | Peptic Ulcer |
| Wound Healing | NEGATIVELY CORRELATED WITH | Peptic Ulcer |
| Reactive Oxygen Species | POSITIVELY CORRELATED WITH | Peptic Ulcer |
Comment: The drug stimulates the expression of several genes (e.g. HSP, SOD, etc) but it’s not clear if the drug binds to these or other targets to modulate the known actions namely oxygen radical scavenging, anti-oxidation, anti-inflammation, and acceleration of gastrointestinal wound healing.
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