Path ID: DB09213_MESH_D001171_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C539402 | dexibuprofen | Drug |
| UniProt:P23219 | Prostaglandin G/H synthase 1 | Protein |
| UniProt:P35354 | Prostaglandin G/H synthase 2 | Protein |
| reactome:R-HSA-2162123 | Synthesis of Prostaglandins (PG) and Thromboxanes (TX) | Pathway |
| MESH:D011453 | Prostaglandins | ChemicalSubstance |
| HP:0002829 | Arthralgia | PhenotypicFeature |
| HP:0001386 | Joint swelling | PhenotypicFeature |
| MESH:D001171 | Arthritis, Juvenile | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Dexibuprofen | DECREASES ACTIVITY OF | Prostaglandin G/H Synthase 1 |
| Dexibuprofen | DECREASES ACTIVITY OF | Prostaglandin G/H Synthase 2 |
| Prostaglandin G/H Synthase 1 | PARTICIPATES IN | Synthesis Of Prostaglandins (Pg) And Thromboxanes (Tx) |
| Prostaglandin G/H Synthase 2 | PARTICIPATES IN | Synthesis Of Prostaglandins (Pg) And Thromboxanes (Tx) |
| Synthesis Of Prostaglandins (Pg) And Thromboxanes (Tx) | INCREASES ABUNDANCE OF | Prostaglandins |
| Prostaglandins | POSITIVELY CORRELATED WITH | Arthralgia |
| Prostaglandins | POSITIVELY CORRELATED WITH | Joint Swelling |
| Joint Swelling | POSITIVELY CORRELATED WITH | Arthritis, Juvenile |
| Arthralgia | POSITIVELY CORRELATED WITH | Arthritis, Juvenile |
Comment: The disease is also known as Juvenile rheumatoid arthritis as per DrugCentral. Dexibuprofen is an active enantiomer of ibuprofen.
Reference: