Path ID: DB09206_MESH_D006973_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C005185 | Trimazosin | Drug |
| UniProt:P35348 | Alpha-1A adrenergic receptor | Protein |
| UniProt:P25100 | Alpha-1D adrenergic receptor | Protein |
| GO:0042310 | Vasoconstriction | BiologicalProcess |
| MESH:D006973 | Hypertensive disorder | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Trimazosin | DECREASES ACTIVITY OF | Alpha-1A Adrenergic Receptor |
| Trimazosin | DECREASES ACTIVITY OF | Alpha-1D Adrenergic Receptor |
| Alpha-1A Adrenergic Receptor | POSITIVELY REGULATES | Vasoconstriction |
| Alpha-1D Adrenergic Receptor | POSITIVELY REGULATES | Vasoconstriction |
| Vasoconstriction | AFFECTS RISK FOR | Hypertensive Disorder |
Comment: Selective action of tamsulosin in alpha 1A/D receptors is controversial and over three quarters of tamsulosin registered human studies are unpublished.
Reference: