Path ID: DB09185_MESH_D009290_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D014745 | Viloxazine | Drug |
| UniProt:P23975 | Sodium-dependent noradrenaline transporter | Protein |
| GO:0051620 | Noradrenaline uptake | BiologicalProcess |
| MESH:D009638 | Noradrenaline | ChemicalSubstance |
| GO:0030431 | Sleep | BiologicalProcess |
| HP:0002524 | Cataplexy | PhenotypicFeature |
| MESH:D009290 | Cataplexy and narcolepsy | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Viloxazine | DECREASES ACTIVITY OF | Sodium-Dependent Noradrenaline Transporter |
| Sodium-Dependent Noradrenaline Transporter | POSITIVELY REGULATES | Noradrenaline Uptake |
| Noradrenaline Uptake | DECREASES ABUNDANCE OF | Noradrenaline |
| Noradrenaline | NEGATIVELY REGULATES | Sleep |
| Noradrenaline | NEGATIVELY REGULATES | Cataplexy |
| Sleep | POSITIVELY CORRELATED WITH | Cataplexy And Narcolepsy |
| Cataplexy | POSITIVELY CORRELATED WITH | Cataplexy And Narcolepsy |
Reference: