Path ID: DB09167_MESH_D003865_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D004308 | dosulepin | Drug |
| UniProt:P31645 | Sodium-dependent serotonin transporter | Protein |
| UniProt:P23975 | Sodium-dependent noradrenaline transporter | Protein |
| GO:0051610 | serotonin uptake | BiologicalProcess |
| GO:0051620 | norepinephrine uptake | BiologicalProcess |
| HP:0000716 | Depressivity | PhenotypicFeature |
| MESH:D003865 | Major depressive disorder | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Dosulepin | NEGATIVELY REGULATES | Sodium-Dependent Serotonin Transporter |
| Dosulepin | NEGATIVELY REGULATES | Sodium-Dependent Noradrenaline Transporter |
| Sodium-Dependent Serotonin Transporter | POSITIVELY REGULATES | Serotonin Uptake |
| Sodium-Dependent Noradrenaline Transporter | POSITIVELY REGULATES | Norepinephrine Uptake |
| Norepinephrine Uptake | POSITIVELY CORRELATED WITH | Depressivity |
| Serotonin Uptake | POSITIVELY CORRELATED WITH | Depressivity |
| Depressivity | MANIFESTATION OF | Major Depressive Disorder |
Reference: