Path ID: DB09122_MESH_D020529_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C428112 | Peginterferon beta-1a | Drug |
| UniProt:P17181 | Interferon alpha/beta receptor 1 | Protein |
| GO:0006954 | Inflammatory response | BiologicalProcess |
| GO:0042100 | B cell proliferation | BiologicalProcess |
| GO:0050798 | Activated T cell proliferation | BiologicalProcess |
| GO:0019882 | Antigen processing and presentation | BiologicalProcess |
| MESH:D020529 | Relapsing remitting multiple sclerosis | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Peginterferon Beta-1A | INCREASES ACTIVITY OF | Interferon Alpha/Beta Receptor 1 |
| Interferon Alpha/Beta Receptor 1 | NEGATIVELY REGULATES | Inflammatory Response |
| Interferon Alpha/Beta Receptor 1 | NEGATIVELY REGULATES | B Cell Proliferation |
| Interferon Alpha/Beta Receptor 1 | NEGATIVELY REGULATES | Activated T Cell Proliferation |
| Interferon Alpha/Beta Receptor 1 | NEGATIVELY REGULATES | Antigen Processing And Presentation |
| Inflammatory Response | POSITIVELY CORRELATED WITH | Relapsing Remitting Multiple Sclerosis |
| B Cell Proliferation | POSITIVELY CORRELATED WITH | Relapsing Remitting Multiple Sclerosis |
| Activated T Cell Proliferation | POSITIVELY CORRELATED WITH | Relapsing Remitting Multiple Sclerosis |
| Antigen Processing And Presentation | POSITIVELY CORRELATED WITH | Relapsing Remitting Multiple Sclerosis |
Comment: Please note that the mechanism by which peginterferon beta-1a exerts its effects in patients with multiple sclerosis is not fully known. Although DrugBank states that Peginterferon beta-1a is an Interferon alpha/beta receptor 1 downregulator, there is an evidence in the literature showing that Peginterferon beta-1a is in fact Interferon alpha/beta receptor 1 activator https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4303928/
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