Path ID: DB09084_MESH_D010146_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D001591 | benzydamine | Drug |
| GO:0006954 | inflammatory response | BiologicalProcess |
| GO:0043312 | neutrophil degranulation | BiologicalProcess |
| MESH:D013373 | Substance P | ChemicalSubstance |
| UniProt:P01375 | Tumor necrosis factor | Protein |
| UniProt:P01584 | Interleukin-1 beta | Protein |
| MESH:D010146 | Pain | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Benzydamine | NEGATIVELY CORRELATED WITH | Tumor Necrosis Factor |
| Benzydamine | NEGATIVELY CORRELATED WITH | Interleukin-1 Beta |
| Tumor Necrosis Factor | POSITIVELY CORRELATED WITH | Inflammatory Response |
| Interleukin-1 Beta | POSITIVELY CORRELATED WITH | Inflammatory Response |
| Benzydamine | NEGATIVELY CORRELATED WITH | Neutrophil Degranulation |
| Neutrophil Degranulation | POSITIVELY CORRELATED WITH | Inflammatory Response |
| Benzydamine | NEGATIVELY CORRELATED WITH | Substance P |
| Substance P | POSITIVELY CORRELATED WITH | Inflammatory Response |
| Inflammatory Response | POSITIVELY CORRELATED WITH | Pain |
Comment: Unlike other NSAIDs, it does not inhibit cyclooxygenase or lipooxygenase (https://en.wikipedia.org/wiki/Benzydamine#Pharmacology).
Reference: