Path ID: DB09083_MESH_D000787_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C088408 | ivabradine | Drug |
| UniProt:Q9UL51 | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 | Protein |
| UniProt:Q9Y3Q4 | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 | Protein |
| GO:0086012 | membrane depolarization during cardiac muscle cell action potential | BiologicalProcess |
| GO:0006936 | muscle contraction | BiologicalProcess |
| MESH:D000787 | Angina pectoris | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Ivabradine | NEGATIVELY REGULATES | Potassium/Sodium Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel 2 |
| Ivabradine | NEGATIVELY REGULATES | Potassium/Sodium Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel 4 |
| Potassium/Sodium Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel 2 | REGULATES | Membrane Depolarization During Cardiac Muscle Cell Action Potential |
| Potassium/Sodium Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel 4 | REGULATES | Membrane Depolarization During Cardiac Muscle Cell Action Potential |
| Membrane Depolarization During Cardiac Muscle Cell Action Potential | REGULATES | Muscle Contraction |
| Muscle Contraction | CORRELATED WITH | Angina Pectoris |
Comment: Both UniProt:Q9UL51 and UniProt:Q9Y3Q4 are slow sodium channels, also known as If channels, where âfâ stands for funny, as per the unusual properties compared with other current systems known at the time of their discovery. Note that out of the two proteins, UniProt:Q9Y3Q4 is the most highly expressed in sinoatrial node myocytes (https://pubmed.ncbi.nlm.nih.gov/17999560/).
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